Vascular depression
Conditions
Interventions
Morinda officinalis oligose capsule group:Morinda officinalis oligose capsule
Placebo group:Placebo
Sponsors
Beijing University of Chinese Medicine Dongfang Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria of Western medicine for vascular depression; 2. Meet the diagnostic criteria of TCM syndrome of kidney deficiency and liver stagnation; 3. Age >= 60 years old; 4. 7 points<=HAMD (17 items)<=24 points; 5. No antidepressant-related western medicine treatment in the past 2 weeks; 6. Voluntarily participate and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Brain MRI shows that the axial extent of cerebral infarction is more than 20mm; 2. Patients with severe neurological deficits such as hemiplegia, aphasia, and agnosia and dementia (MMSE score: illiteracy <=17 points, primary school education level <=20 points, secondary school education level <=24, etc.); 3. Patients with bipolar disorder, schizophrenia, refractory depression or suicidal tendencies; 4. Found patients with serious organic diseases such as heart, liver and kidney; 5. The head and neck arteries have been treated with endarterectomy or stenting; 6. Suffering from cerebral vasculitis, intracranial aneurysm, encephalitis, meningitis, intracranial vascular malformation, brain tumor, etc.; 7. Patients with epilepsy, poisoning, drug abuse, innate immune diseases, and genetic diseases; 8. Have a history of allergies to multiple drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton Depression Scale 17; | — |
Secondary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment;Hamilton Anxiety Scale;Athens Insomnia Scale;TCM syndrome scores;Fazekas scale;Activity of Daily Living score; | — |
Countries
China
Contacts
Public ContactGuo Rongjuan
Beijing University of Chinese Medicine Dongfang Hospital
Outcome results
None listed