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Investigation of the clinical effect and mechanism of combining multi-module 3D virtual reality (VR) and repetitive transcranial magnetic stimulation for the treatment of post-stroke memory disorders

Investigation of the clinical effect and mechanism of combining multi-module 3D virtual reality (VR) and repetitive transcranial magnetic stimulation for the treatment of post-stroke memory disorders

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2100049034
Enrollment
Unknown
Registered
2021-07-20
Start date
2021-08-01
Completion date
Unknown
Last updated
2022-04-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stroke

Interventions

the test group A:rTMS
the test group B:Virtual reality (VR)
the test group C:rTMS and VR

Sponsors

Sichuan Provincial People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
35 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1.According to the diagnostic criteria of stroke formulated by the fourth national cerebrovascular conference; 2.The first onset was diagnosed as a single lesion by CT or MRI. The lesion did not involve the hippocampus and parahippocampal gyrus. The clinical data were complete; 3.During the study period, the patient's condition was stable, consciousness and consciousness were clear, MMSE score was more than 17, and Rivermead behavioral memory test showed memory loss; 4.Age 35-75 years old; 5.Cooperating with the research, willing to accept functional magnetic resonance examination, without MRI contraindications; 6.The patient or his family members voluntarily signed the informed consent.

Exclusion criteria

Exclusion criteria: 1.Intracranial organic lesions (space occupying, vascular malformation, infection, trauma, congenital dysplasia); 2.He had a history of stroke, epilepsy, dementia and depression; 3.The vital signs are not stable or the liver and kidney function are obviously damaged. 4.Those with metal implants (such as cardiac stents) in the body; 5.Patients with severe audiovisual impairment and claustrophobia.

Design outcomes

Primary

MeasureTime frame
Mini Mental State Assessment (MMSE);Rivermead Memory test;Attention assessment;fMRI;MoCA assessment scale;

Secondary

MeasureTime frame
Fugl Meyer assessment of motor function;Modified bathel index;

Countries

China

Contacts

Public ContactXu Li

Sichuan Provincial People's Hospital

xuli_0125@163.com+86 18908010201

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026