Acute Myocardial Infarction
Conditions
Interventions
The test group:dapagliflozin is added to the conventional treatment
The control group:the conventional treatment
Sponsors
Hunan Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Patient with age more than 18 years old and less than 80 years old; 2.Patient is diagnosed with acute myocardial infarction and have already underwent percutaneous coronary intervention; 3.The left ventricular ejection fraction (LVEF) is less than 50% ; 4.Patient is willing to sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Type 1 diabetes; 2. Severe renal insufficiency (eGFR less than 30ml/min/1.73?); 3. Mechanical complications of acute myocardial infarction, such as ventricular septal perforation; 4. Systolic blood pressure less than 100mmHg; 5. Active hematuria or urinary tract infection; 6. SGLT2 inhibitors have been used; 7. Diseases that can affect the NLRP3 inflammasome signaling pathway: obesity (BMI>30kg/?), gout, silicosis, Alzheimer's disease, active hepatitis, malignant tumors, autoimmune diseases such as rheumatoid arthritis , Ankylosing spondylitis, take antioxidant drugs, such as vitamin E; 8. Combined with severe disease with expected survival time of less than 6 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Left ventricular end-diastolic volume;left ventricular ejection fraction; | — |
Secondary
| Measure | Time frame |
|---|---|
| IL-1ß and IL-18; | — |
Countries
China
Contacts
Public ContactPeng Jianqiang
Hunan Provincial People's Hospital
Outcome results
None listed