perioperative depressive mood disorder
Conditions
Interventions
Es-Ketamine (group A) :Group A was given 0.5mg/kg ketamine during anesthesia induction
Normal saline group (group B):Group B was given the same dose of normal saline during anesthesia induction
Sponsors
The Second Xiangya Hospital of Central South University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients diagnosed with lung cancer by preoperative or intraoperative pathology and followed by thoracoscopic partial pneumonectomy; 2. Aged 18 to 65 years, BMI 18~25, ASA I~III; 3. Have a full understanding of this study, and voluntarily sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Cognitive dysfunction; 2. Schizophrenia, use of other antidepressants within the last two weeks, and history of drug abuse. 3 hearing and language expression disorders, unable to communicate; 4. Hypertensive patients, hyperthyroidism patients, diabetes patients with poor control or untreated, intolerance or allergy to ketamine, propofol, sufentanil and other drugs combined with ketamine contraindications such as glaucoma; 5. The operation type is lung wedge resection; 6, abnormal liver function (ALT and/or AST>1.5 times the upper limit of normal value or total bilirubin >=1.5 times the upper limit of normal value), abnormal renal function, serum creatinine >1.5 times the upper limit of normal value or creatinine clearance = N at screening time); Or other cardiac function abnormalities judged by the investigator to be abnormal and clinically significant; 8. Relevant researchers of this study; 9. Participated in other clinical trials within 4 weeks before surgery; 10. Can't understand the study procedure and the use of the pain scale, as judged by the researcher, and can't effectively communicate with the researcher; 11. There are other circumstances that the investigator judges are not suitable for participating in the clinical study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MADRS depression scale score;Plasma levels of BDNF(Brain derived neurotrophic factor);visual analogue scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| SF-MPQ;Postoperative opioids;The length of time; | — |
Countries
China
Contacts
Public ContactLi Zhijian
The Second Xiangya Hospital of Central South University
Outcome results
None listed