Major depressive disorder
Conditions
Interventions
Sponsors
The Second People's Hospital of Guizhou
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Inpatients (during 5 consecutive days of treatment); 2. 18-65 years old, male or female; 3. Primary DSM-V diagnosis of major depressive disorder, first course or relapse; 4. HRSD-24 score >= 21; 5. The duration of the current episode is less than one year; 6. The patient did not respond well to at least one antidepressant treatment during the course of this depressive episode (may appear before admission), or the patient was intolerant to two or more antidepressant treatment in this episode ; 7. Pass the safety screening of transcranial magnetic stimulation; 8. Ability and willingness to provide informed consent and be able to comply with the treatment plan; 9. Patients have been on stable medication (unlimited) for at least 4 weeks and are not expected to change medications during the study period.
Exclusion criteria
Exclusion criteria: 1. Severe psychotic symptoms, such as persecutory delusions, etc. during the current episode; 2. DSM-V diagnosis of substance dependence in the past 6 months (any type); 3. Concurrent, serious and unstable physical diseases, such as cardiovascular and cerebrovascular diseases; 4. Pregnant or lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton Depression Scale;Montgomery-Asperger Depression Rating Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hamilton Anxiety Scale;Baker Suicide Scale; | — |
Countries
China
Contacts
Public ContactShu Yanping
The Second People's Hospital of Guizhou
Outcome results
None listed