Knee osteoarthritis
Conditions
Interventions
KOA group:Total knee arthroplasty
Non-KOA group:Arthroscopic knee surgery
Sponsors
Kunshan Third People's Hospital
Eligibility
Sex/Gender
All
Age
40 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. KOA group (1) For patients with knee osteoarthritis, the KOA diagnostic criteria in the 2007 edition of "Guidelines for the Diagnosis and Treatment of Osteoarthritis": 1) Repeated knee pain within 1 month; 2) X-ray films showed joint space narrowing, subchondral bone sclerosis and/or cystic degeneration, and osteophyte formation at the joint edge; 3) Clear joint fluid, WBC= 40 years; 5) Morning stiffness = 4). 2. Inclusion criteria for non-KOA group: (1) Aged >=40 years; (2) No previous history of knee fracture; (3) Arthroscopic surgery is required for discoid meniscus, meniscus injury, popliteal cyst, etc.; (4) Outerbridge arthroscopic cartilage injury grade 1 month.
Exclusion criteria
Exclusion criteria: 1. Those with skin ulceration of the knee joint, or those with a history of surgery or intra-articular hormone injection; 2. Immune and immune-related arthritis, such as gouty arthritis, rheumatoid arthritis, reactive arthritis, psoriatic arthritis, etc.; 3. Patients with renal insufficiency and a history of malignant tumors; 4. Infectious arthritis, tuberculosis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visual analogue scale;Nerve growth factor; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain sensitivity threshold;Skin temperature;Tyrosine kinase A;Transient receptor potential vanillic acid subtype 1; | — |
Countries
China
Contacts
Public ContactLi Mingchao
Kunshan Third People's Hospital
Outcome results
None listed