Small intestine lesion and celiac disease
Conditions
Interventions
case series:None
Sponsors
The First Affiliated Hospital of Sun Yat-Sen University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-65 years, gender is not limited; 2. Outpatient or inpatient patients who meet the Rome III diagnostic criteria for IBS; 3. No organic disease was found by routine tests such as blood test, gastroscope, colonoscopy, abdominal ultrasound (the results are valid within 1 year).
Exclusion criteria
Exclusion criteria: 1. History of previous gastrointestinal surgery, suspected incomplete gastrointestinal obstruction, intestinal adhesions, strictures, fistulas and other conditions that may cause intestinal obstruction; 2. Intestinal organic diseases such as inflammatory bowel disease, infectious bowel disease, and intestinal tumor (intestinal polyps <=5mm can still be added); 3. Hyperthyroidism, diabetes, myasthenia gravis and other systemic diseases that may affect the function of the gastrointestinal tract; 4. Those who need to take hormones, immunosuppressants, NSAIDs, anticoagulants and other drugs that the researchers think may affect the study for a long time and cannot stop the drugs; 5. Those who are pregnant or who cannot be used for effective contraception during the research period; 6. Those who are unable to cooperate with severe mental and psychological diseases or serious systemic diseases; 7. Those who have implanted cardiac pacemakers or other electronic devices; 8. Those who have no conditions for abdominal surgery or who refuse to accept abdominal surgery; 9. Patients who have difficulty swallowing and cannot swallow capsule endoscopy; 10. Patients who are judged by the investigator to be unsuitable to participate in clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Detection rate of small intestine lesion;Seropositive rate of celiac disease antibody;Small bowel transit time for capsule endoscopy; | — |
Secondary
| Measure | Time frame |
|---|---|
| Genetic testing (HLA-DQ2 and/or HLA-DQ8) positive rate; | — |
Countries
China
Contacts
Public ContactChen Minhu
The First Affiliated Hospital of Sun Yat-Sen University
Outcome results
None listed