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Application value of DNA gene methylation markers in triage of HPV-positive patients in cervical cancer screening

Application value of DNA gene methylation markers in triage of HPV-positive patients in cervical cancer screening

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2100048972
Enrollment
Unknown
Registered
2021-07-19
Start date
2021-08-01
Completion date
Unknown
Last updated
2022-03-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Uterine Cervical Lesions

Interventions

Gold Standard:Pathological results of cervical biopsy. This project will perform colposcopy biopsy and/or cervical canal scraping within 12 weeks after the completion of HPV+TCT screening according to

Sponsors

International Peace Maternity and Child Health Hospital, Shanghai Jiaotong University School of Medicine
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
30 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Females aged >= 30 years with a history of sexual life. 2. The initial hrHPV DNA test in the clinic is positive, and the remaining cell samples for hrHPV testing can be collected. 3. Sign the informed consent form, be willing and able to accept colposcopy, and have histological results that meet the diagnostic criteria. 4. No history of cervical cancer and precancerous lesions treatment.

Exclusion criteria

Exclusion criteria: 1. Pregnant women; 2. Women with immunodeficiency; 3. Women with a history of other gynecological malignancies and tumors; 4. Women with incomplete personal information: sample collection unit, name, age, cytology test results, HPV test results, colposcopy pathology results, cytology history within 5 years, and history of colposcopy within 5 years.

Design outcomes

Primary

MeasureTime frame
DNA methylation;

Countries

China

Contacts

Public ContactWang Yudong

International Peace Maternity and Child Health Hospital, Shanghai Jiaotong University School of Medicine

owangyudong@126.com+86 18017316053

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 9, 2026