Urinary system diseases
Conditions
Interventions
Urinary tract infection and cystitis group:Transplantation of fecal bacteria and urinary bacteria
Urinary calculi group:Transplantation of fecal bacteria and urinary bacteria
Kidney cancer group:Transplantation of fecal bacteria and urinary bacteria
Bladder cancer group:Transplantation of fecal bacteria and urinary bacteria
Prostate cancer group:Transplantation of fecal bacteria and urinary bacteria
Benign prostatic hyperplasia group:Transplantation of fecal bacteria and urinary bacteria
Prostatitis group:Transplantation of fecal bacteria and urinary bacteria
Sponsors
Affiliated Wuxi No.2 Hospital of Nanjing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Urinary tract infection and cystitis group (1) Inclusion criteria for the trial group: 1) Aged>=18 years and >=3 times of urinary tract infection in the past 1 year / >=2 times in the past 6 months, and the current occurrence of urinary tract infection or (and) cystitis. Urinary tract infection and cystitis diagnostic criteria: urine culture with the same colony >= 10^3 cfu/mL, urine analysis WBC >= 10/mm^3; urinary tract irritation such as frequent urination, urgency, dysuria, or lower abdominal tenderness, and tenderness in the kidney area, With or without fever; 2) Voluntarily participate in this study; 3) Be awake; 4) Be able to communicate normally. (2) Inclusion criteria for the control group: 1) No urinary tract infection in the past 1 month; 2) Completely matched with the patient group in terms of age (5 years old as a group), gender, marriage and menstruation. 2. Urinary calculus group (1) Inclusion criteria for the experimental group: 1) Patients aged >= 18 years and all patients met the clinical diagnostic criteria for renal ureteral calculi and met the relevant content in the Chinese Guidelines for Diagnosis and Treatment of Stone Diseases; 2) Voluntarily participate in this study; 3) Be awake; 4) Be able to communicate normally. (2) Inclusion criteria for the control group: 1) No history of urinary calculi; 2) Completely matched with the patient group in terms of age (5 years old as a group), gender, marriage and menstruation. 3. Kidney cancer group (1) Inclusion criteria for the experimental group: 1) Aged >= 18 years and the patient was diagnosed with renal cancer by abdominal CT and postoperative pathological examination; 2) Volunteered to participate in this study; 3) Be conscious; 4) Able to communicate normally. (2) Inclusion criteria for the control group: 1) Physically healthy; 2) Completely matched with the patient group in terms of age (5 years old as a group), gender, marriage and menstruation. 4. Bladder cancer group (1) Inclusion criteria for the experimental group: 1) Aged >=18 years and the patient was diagnosed with bladder cancer by imaging examination and postoperative pathological examination; 2) Volunteered to participate in this study; 3) Be conscious; 4) Able to communicate normally. (2) Inclusion criteria for the control group: 1) Physically healthy; 2) Completely matched with the patient group in terms of age (5 years old as a group), gender, marriage and menstruation. 5. Prostate cancer group (1) Inclusion criteria for the experimental group: 1) Aged >=18 years and the patient was diagnosed with prostate cancer by imaging examination and postoperative pathological examination; 2) Volunteered to participate in this study; 3) Be conscious; 4) Able to communicate normally. (2) Inclusion criteria for the control group: 1) Physically healthy; 2) Completely matched with the patient group in terms of age (5 years old as a group), gender, marriage and menstruation. 6. Prostate hyperplasia group (1) Inclusion criteria for the experimental group: 1) Aged >= 18 years and the clinical manifestations, physical examination and imaging examinations of the patients all meet the diagnostic criteria for benign prostatic hyperplasia; 2) Voluntarily participate in this study; 3) Consciousness; 4) Can communicate normally. (2) Inclusion criteria for the control group: 1) Physically healthy; 2) Completely matched with the patient group in terms of age (5 ye
Exclusion criteria
Exclusion criteria: 1. Urinary tract infection and cystitis group (1) Exclusion criteria for the experimental group: 1) Those who currently receive indwelling catheterization; 2) Those who have used antibiotics in the past 1 week; 3) Those who have used probiotics or synbiotics in the past 1 month; 4) Those who have the following conditions: Idiopathic cystitis, fever, acute and chronic pyelonephritis, acute and chronic prostatitis, urethritis, epididymitis, urinary incontinence, urethral malformation, bladder neck protrusion, hydronephrosis, renal atrophy, neurocystitis, tuberculosis, pregnancy, menstrual period, lactation period, severe cardiovascular, liver, kidney disease, mental disorders. (2) Exclusion criteria for the control group: 1) Those who currently receive indwelling catheterization; 2) Those who have used antibiotics in the past 1 week; 3) Those who have used probiotics or synbiotics in the past 1 month; 4) Those who have the following conditions: Idiopathic cystitis, fever, acute and chronic pyelonephritis, acute and chronic prostatitis, urethritis, epididymitis, urinary incontinence, urethral malformation, bladder neck protrusion, hydronephrosis, renal atrophy, neurocystitis, tuberculosis, pregnancy, menstrual period, lactation period, severe cardiovascular, liver, kidney disease, mental disorders; 5) Severe systemic infection. 2. Urinary calculus group (1) Exclusion criteria for the experimental group: 1) Those who currently receive indwelling catheterization; 2) Those who have used antibiotics in the past 1 week; 3) Those who have used probiotics or synbiotics in the past 1 month; 4) Those who have the following conditions: Idiopathic cystitis, fever, acute and chronic pyelonephritis, acute and chronic prostatitis, urethritis, epididymitis, urinary incontinence, urethral malformation, bladder neck protrusion, hydronephrosis, renal atrophy, neurocystitis, tuberculosis, pregnancy, menstrual period, lactation period, severe cardiovascular, liver, kidney disease, mental disorders; 5) Severe systemic infection; 6) There is a history of tumor. (2) Exclusion criteria for the control group: 1) Those who currently receive indwelling catheterization; 2) Those who have used antibiotics in the past 1 week; 3) Those who have used probiotics or synbiotics in the past 1 month; 4) Those who have the following conditions: Idiopathic cystitis, fever, acute and chronic pyelonephritis, acute and chronic prostatitis, urethritis, epididymitis, urinary incontinence, urethral malformation, bladder neck protrusion, hydronephrosis, renal atrophy, neurocystitis, tuberculosis, pregnancy, menstrual period, lactation period, severe cardiovascular, liver, kidney disease, mental disorders; 5) Severe systemic infection; 6) There is a history of tumor. 3. Kidney cancer group (1) Exclusion criteria for the experimental group: 1) Those who currently receive indwelling catheterization; 2) Those who have used antibiotics in the past 1 week; 3) Those who have used probiotics or synbiotics in the past 1 month; 4) Those who have the following conditions: Idiopathic cystitis, fever, acute and chronic pyelonephritis, acute and chronic prostatitis, urethritis, epididymitis, urinary incontinence, urethral malformation, bladder neck protrusion, hydronephrosis, renal atrophy, neurocystitis, tuberculosis, pregnancy, menstrual period, lactation period, severe cardiovascular, liver, kidney disease, mental disorders; 5) Severe systemic infection; 6) C
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| glycosylated hemoglobin;renal function;S - creatinine;C-reactive protein;serum lipid;estrogen;endotoxin;CD3 and CD4;urine IgA;blood IgA;urine analysis;urine culture;16S rRNA sequencing of urine;16S rRNA sequencing of feces;urological imaging examination;cystoscopy;liver function;basic information of patients;water intake; | — |
Countries
China
Contacts
Public ContactFeng Ninghan
Affiliated Wuxi No.2 Hospital of Nanjing Medical University
Outcome results
None listed