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Application of human follicle-stimulating hormone individualized drug delivery platform to in vitro fertilization-embryo transfer technology

Application of building an individualized drug delivery platform for human follicle-stimulating hormone based on pharmacogenomics and population pharmacokinetics

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2100048961
Enrollment
Unknown
Registered
2021-07-19
Start date
2021-09-01
Completion date
Unknown
Last updated
2022-03-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

infertility

Interventions

Experimental group:In vitro fertilization-embryo transfer assisted pregnancy using the COS protocol suggested by the FSH drug delivery platform
Control group:Conventional IVF-Embryo Transfer Assisted Pregnancy

Sponsors

The Affiliated Reproductive Hospital of China Medical University
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 40 Years

Inclusion criteria

Inclusion criteria: 1. The woman aged 20-40 years; 2. Clinical treatment requires in vitro fertilization-embryo transfer (IVF/ICSI-ET) assisted pregnancy; 3. AMH>=1.2ng/ml, AFC>=10; 4. Voluntarily sign the informed consent.

Exclusion criteria

Exclusion criteria: 1. Physical examination patients with contraindications for assisted reproduction, such as liver and kidney dysfunction, autoimmune diseases, acute phase of infectious diseases, untreated endocrine diseases, severe endometriosis and large ovarian cysts ; 2. Abnormal karyotype analysis, suffering from family genetic diseases, etc.; 3. Patients with azoospermia on the male side; 4. Patients who are participating in other clinical trials; 5. The researchers believe that they are not suitable to participate in this clinical trial.

Design outcomes

Primary

MeasureTime frame
Number of eggs retrieved;Ovarian hyperstimulation syndrome incidence;Elimination of embryo transfer rates to avoid ovarian hyperstimulation;FORT value;Total follicle stimulating hormone dose;Follicle stimulating hormone starting dose;Ovulation induction days;Fresh-cycle embryo transfer rates;The high quality embryo rate;The proportion of 10-15 oocyte cycles;

Secondary

MeasureTime frame
HCG day serum estradiol level;The fertilization rate;The clinical pregnancy rate;

Countries

China

Contacts

Public ContactSui Yang

The Affiliated Reproductive Hospital of China Medical University

suiyang2014@163.com+86 13940066656

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026