Stroke
Conditions
Interventions
Exposed group:Short-term intracortical inhibition of the non-involved motor cortex was greater than 1
Non-exposed group:Short-term intracortical inhibition of the non-involved motor cortex was less than or equal to 1
Sponsors
Jing'an District Centre Hospital of Shanghai, Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. First onset, consistent with the diagnostic criteria of stroke at the 4th National Conference on Cerebrovascular Diseases in 1995, confirmed by cranial CT or MRI, and indicated unilateral subcortical lesions; 2. Right-handed, aged 18 to 90 years, weight not less than 40kg; 3. Course of disease: patients with post-stroke hemiplegia after acute stage, i.e., were enrolled on the 7th day after onset; 4. The presence of hemiplegia of one limb; 5. Subjects should receive standard physical/occupational therapy; 6. The subject's general condition and vital signs are stable, with normal level of consciousness and no visual or auditory impairment; 7. The MMSE score meets the following criteria: 17 in the illiteracy group (no education), 20 in the primary school group ( 6 years of education);According to the judgment of the researcher, the subject must clearly understand the purpose of the study, and be willing and able to comply with the requirements to complete the entire study; 8. Subjects have no previous history of brain injury, brain injury, stroke, intracranial tumor, other central nervous system diseases or surgical history of central nervous system surgery; 9. Subjects voluntarily participate in the study and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Epilepsy patients; 2. The limb under study has severe contracture or lesions that interfere with the study; 3. Plan to perform phenol or alcohol block, cast, botulinum toxin to treat the spasticity of the upper extremity of the patient; 4. During this trial, new anticonvulsants are planned or expected to be used; 5. Patients who are pregnant, breastfeeding, pregnant during the planned trial, or women of childbearing age who do not take reliable contraceptive measures; 6. Patients with serious primary diseases such as heart, liver, kidney, hematopoietic system and endocrine system, and mental illness; 7. Those with poor compliance and unable to complete the test; 8. Patients with metallic foreign bodies (pacemakers, arterial stents, etc.); 9. There are contraindications to magnetic resonance examination.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Modified Ashworth scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Resistance to passive movement scale;Fugl-Meyer function assessment;Modified barthel index;Acoustic startle reflex;Sensory evoked potential;Motor evoked potential;Regions of interest activated voxel value;Lateralization indices;Fractional anisotropy;Functional links in brain regions; | — |
Countries
China
Contacts
Public ContactWang Bei
Jing'an District Centre Hospital of Shanghai, Fudan University
Outcome results
None listed