Type 2 Diabetes Mellitus Related Cognitive Dysfunction
Conditions
Interventions
Type 2 diabetes with cognitive impairment group:None
Type 2 diabetes without cognitive impairment group:None
Sponsors
The First Affiliated Hospital of Guangzhou University of Chinese Medicine
Eligibility
Sex/Gender
All
Age
50 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Aged 50-60 years; 2. Right-handed; 3. High school to undergraduate education level; 4. Patients diagnosed with type 2 diabetes meet the general diagnostic criteria for diabetes, including symptoms of diabetes (polydipsia, polyphagia, polyuria, weight loss, etc.) and random blood sugar >11.1mmol/L, fasting blood sugar >=7.0mmol/L, 2h blood sugar after 75g glucose load (OGTT) >=11.1mmol/L; 5. Use insulin therapy only to control blood sugar.
Exclusion criteria
Exclusion criteria: 1. Have used antibiotics within 6 months before the start of the study; 2. Use drugs other than insulin to control blood glucose level; 3. Comorbid with severe hypertension, COPD, heart failure, or severe dyslipidemia; 4. With other endocrine diseases, severe organ dysfunction with heart or kidney insufficiency; 5. Combined with tumor diseases; 6. In the menstrual period when participating in the research; 7. Pregnant or lactating patients; 8. There are hearing, vision, or language barriers; 9. Diagnosed by an experiencing psychiatrist with a mental or emotional illness; 10. Concomitant or discovered through brain structural MRI examination, with neurological degenerative diseases, brain trauma or cerebrovascular diseases, and other organic brain diseases; 11. There are metal implants or other magnetic resonance contraindications; 12. Patients with claustrophobia; 13. Other types of diabetes.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Simple Mental Status Checklist Results;Montreal Cognitive Assessment;16s RNA Sequencing;3D T1-Weighted Image;Diffusion Spectrum Imaging;Resting State Functional Magnetic Resonance Imaging;Serum Metabolomics; | — |
Secondary
| Measure | Time frame |
|---|---|
| Auditory Verbal Learning Test;Complex Figure Test;The Trail-Making Test;Clock Drawing Test;Digit Span Test;Grooved Pegboard;Digit Symbol Substition Test;High-Density Lipoprotein;Low Density Lipoprotein;Total Cholesterol;Triglyceride;Thyroxine T3;Thyroxine T4;Thyroid Stimulating Hormone;Glycosylated Hemoglobin;Fasting Plasma Glucose; | — |
Countries
China
Contacts
Public ContactQiu Shijun
The First Affiliated Hospital of Guangzhou University of Chinese Medicine
Outcome results
None listed