Clinical study on the role of BNIP3-mediated autophagy pathway in severe hand-foot-mouth disease complicated with brain injury

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2100048859

Enrollment

Unknown

Registered

2021-07-18

Start date

2021-07-23

Completion date

Unknown

Last updated

2022-03-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hand-foot-mouth disease

Interventions

Gold Standard:Hand, foot and mouth disease diagnosis and treatment are carried out in accordance with the diagnosis and treatment guidelines. Make a diagnosis based on the child's clinical manifestati

Index test:1.&#32

BNIP3,&#32

LC3-II,&#32

LC3-I,&#32

Beclin-1,&#32

Parkin,&#32

P62&#32

of&#32

Serum&#32

and&#32

cerebrospinal&#32

fluid

2.&#32

NSE?S100B&#32

Serum.

Eligibility

Sex/Gender

All

Age

0.5 Years to 6 Years

Inclusion criteria

Inclusion criteria: 1. According to the "Guidelines for the Diagnosis and Treatment of Hand, Foot and Mouth Disease (2018 Edition)"; 2. Aged from 6 months to 6 years; 3. The children with HFMD who were hospitalized in the hospital during the study period were all new cases. without brain injury, epilepsy, brain dysplasia and other diseases.

Exclusion criteria

Exclusion criteria: 1. Parents refuse to participate in the program or withdraw early, resulting in incomplete data; 2. Respiratory Tract, urinary tract and other system infections during hospitalization.

Design outcomes

Primary

Measure	Time frame
BNIP3;LC3-II;LC3-I;Beclin-1;Parkin;P62;	—

Secondary

Measure	Time frame
NSE;S100B;	—

Countries

China

Contacts

Public ContactZhu Lei

Xuzhou Children's Hospital

xuzhouzhulei317@163.com+86 13685134366

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026