Obese patients undergoing laparoscopic surgery
Conditions
Interventions
Experimental Group:calcium gluconate 20mg/kg+neostigmine 40ug/kg
Neostigmine Group:neostigmine 40ug/kg
Calcium Group:calcium gluconate 20mg/kg
Blank Group:same amount of normal saline
Sponsors
Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Aged from 18 to 60 years; 2. ASA grade II or III; 3. Obese patients undergoing elective laparoscopic surgery(BMI>=30kg/m2).
Exclusion criteria
Exclusion criteria: 1. Difficult airway; 2. Past history of asthma, chronic obstructive pulmonary disease, acute lung injury or acute respiratory distress syndrome within 3 months before surgery; 3. Preoperative abnormal liver and renal function; 4. Patients with neuromuscular diseases are taking drugs that affect the duration and intensity of neuromuscular block drugs; 5. Hypercalcemia or hypocalcemia; 6. Allergies to the drugs used; 7. History of malignant high fever; 8. Neostigmine, atropine and calcium with contraindication; 9. Participating in other relevant clinical trials or refusing to participate in the trials; 10. Attending estimated surgical time 4h.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| neuromuscular recovery time; | — |
Secondary
| Measure | Time frame |
|---|---|
| incidence of RNMB; serum calcium ion concentration;incidence of postoperative pulmonary complications; | — |
Countries
China
Contacts
Public ContactYan Ming
Department of Anesthesiology, Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed