mild traumatic brain injury
Conditions
Interventions
experimental group 1:iTBS treatment
experimental group 2:HF-rTMS treatment
control group:sham stimulation
Sponsors
China Rehabilitation Research Center
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Patients with a clear history of head trauma: (1) Loss of consciousness for less than 30 minutes; (2) Consciousness/mental state change <24h; (3) Posttraumatic amnesia <1d; (4) Normal imaging structure or a small amount of intracranial hemorrhage or mild brain contusion confirmed by CT; (5) The Glasgow Coma Scale score ranged from 13 to 15; 2. Meet one of the following conditions: (1) Patient complained of memory loss; (2) Wechsler memory scale and N-back examination showed memory disorder; (3) MoCA scale score was greater than 15, and memory impairment was suggested; 3. Aged from 18 to 60 years, can cooperate with the relevant examination and treatment; 4. Patients and their family members were informed of the examination and treatment procedures of this study, and signed the informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with other severe nervous system diseases and unstable central nervous system symptoms; 2. Concomitant history of epilepsy, alcohol/drug abuse or mental illness; 3. TMS treatment cannot be performed if there are metal foreign bodies or other implanted electronic devices in the body; 4. Patients with metal foreign body or any electronic device implanted in the body or with contraindication of fMRI such as claustrophobia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Wechsler Memory Scale;N-back mission training;rest-fMRI; | — |
Secondary
| Measure | Time frame |
|---|---|
| HDRS-24;HAMA;Beck Depression Inventory;Mini-Mental State Examimation;Montreal Cognitive Assessment;Wechsler Intelligence Scale;Wsiconsin card sorting test; | — |
Countries
China
Contacts
Public ContactZhang Hao
China Rehabilitation Research Center
Outcome results
None listed