A non-inferiority study of minimally invasive anesthesia based on modified intercostal block versus traditional general anesthesia combined with thoracic epidural anesthesia in enhanced recovery protocol for lung resection

Non-inferiority comparison of minimally invasive anesthesia based on modified intercostal block versus traditional general anesthesia combined with thoracic epidural anesthesia in enhanced recovery protocol for thoracoscopic lung resection:Multicenter, open-ended, randomized trial

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100048835

Enrollment

Unknown

Registered

2021-07-18

Start date

2021-07-24

Completion date

Unknown

Last updated

2022-10-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pulmonary nodules/tumors

Interventions

Minimally invasive ERAS group:Minimally invasive anesthesia based on modified intercostal block

Epidural ERAS Group:Combined Anesthesia based on thoracic epidural anesthesia

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1. Patients who can sign informed consent; 2. Patients who scheduled to undergo thoracoscopic lobectomy; 3. Aged from 18 to 70 years; 4. ASA class I-III.

Exclusion criteria

Exclusion criteria: 1. Patients with contraindications to regional block technology (those with local anesthetic allergy, infection around puncture site and coagulation disorders); 2. Dementia patients with any communication difficulties or had any cerebrovascular accident in the last three months, such as a stroke or transient cerebral ischemia; 3. Patients with heart rate < 50 times/min or type II-III atrioventricular block; 4. Patients who are allergic to the study drug; 5. Contraindications to epidural surgery, such as abnormal coagulation, column deformity, etc; 6. Confirmed/suspected abuse of narcotic sedative and analgesic drugs; 7. Patients with previous gastrointestinal ulcer or platelet abnormality; 8. Patients transferred to thoracotomy; 9. Patients who cancel the use of analgesia pump for various reasons.

Design outcomes

Primary

Measure	Time frame
The incidence of major complications after thoracic surgery;	—

Secondary

Measure	Time frame
Postoperative rest/ coughing VAS score;Exhaust time;Time out of bed;Tramadol usage;Sleep Quality Score;Length of postoperative stay;Mortality;Postoperative chronic pain and tumor recurrence rate;Quality of life after surgery;Perioperative hypotension;Opioid-related side effects;	—

Countries

China

Contacts

Public ContactCheng Xinqi

The First Affiliated Hospital of Anhui Medical University

ay_mz_cheng@126.com+86 551 62922344

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026