Advanced rectal cancer
Conditions
Interventions
pCR group:surgical resection after neoadjuvant treatment
Non-pCR group:surgical resection after neoadjuvant treatment
Sponsors
Yunnan Cancer Hospital (The Third Affiliated Hospital of Kunming Medical University)
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Patients with rectal cancer confirmed by colonoscopy and biopsy; 2. Clinical stage is T3, T4 locally advanced patients, and the lesion range is >=1.0cm; 3. Inflexible Proctoscopy examines the lower edge of the tumor within 10 cm from the anal edge; 4. Untreated patients at first diagnosis; 5. Patients without contraindications to magnetic resonance examination; 6. surgery after neoadjuvant treatment, and After the operation, complete materials were collected and TRG graded.
Exclusion criteria
Exclusion criteria: 1. Patients who abandon treatment or change therapy during the treatment; 2. Patients with multiple cancers; 3. Patients with poor multimodal MR imaging image quality.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The ADC signal; | — |
Secondary
| Measure | Time frame |
|---|---|
| APTw;DKI parameters;IVIM parameters;Multimodal MRI;MSI Type;Tumor budding grade;KRAS, NRAS, BRAF gene mutations and mutation type;Carcinoembryonic antigen;Carbohydrate antigen 19-919-9;TRG classification; | — |
Countries
China
Contacts
Public ContactLi Zhenhui
Yunnan Cancer Hospital (The Third Affiliated Hospital of Kunming Medical University)
Outcome results
None listed