Incision pain after posterior cervical single open-door laminoplasty
Conditions
Interventions
Ropivacaine group:local wound infiltration with ropivacaine and normal saline
Ropivacaine + dexamethasone group:local wound infiltration with ropivacaine and dexamethasone
Ropivacaine + dexmedetomidine group:local wound infiltration with ropivacaine and dexmedetomidine
Sponsors
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
20 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. After fully informed of the benefits and risks of the trial, patient agreed to participate in the trial and voluntarily signed the informed consent; 2. Aged from 20 to 70 years; 3. Patients had the clinical manifestations of upper and / or lower extremity nerve compression,and confirmed by MRI and or CT as cervical spondylotic myelopathy, congenital cervical spinal canal stenosis or ossification of the posterior longitudinal ligament , and required for posterior cervical single open-door laminoplasty; 4. Conservative treatment included physical therapy, pain medication and local block therapy were ineffective for at least 3 months; 5. The grade of American Society of anesthesiologists is classified as I-II; 6. Patient controlled analgesia device (PCA) can be used independently.
Exclusion criteria
Exclusion criteria: 1. Previous history of cervical instrumentation implantation; 2. Known allergy to test drugs (dexamethasone, dexmedetomidine, ropivacaine, parecoxib, ibuprofen); 3. Nerve compression symptoms caused by cervical or other tumors; 4. Ischemic heart disease, bradycardia (heart rate 35), Weight <=50 kg, liver and kidney dysfunction); 6. Long-term use of hormones or sedative analgesics; 7. Systemic or local active or chronic infection, such as AIDS, syphilis, hepatitis; 8. Severe mental illness (psychosis, severe affective disorder or schizophrenia); 9. Recent or previous history of alcohol, opioid or narcotic drug dependence; 10. Autoimmune diseases affecting musculoskeletal system (such as systemic lupus erythematosus, rheumatoid arthritis, ankylosing spondylitis); 11. Pregnant or ready to be pregnant; 12. For mental or physical reasons, they can't master the PCA device, or they can't answer the pain questionnaire.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The time of first use of analgesics; | — |
Secondary
| Measure | Time frame |
|---|---|
| Total usage of hydromorphone in PCA;NRS pain scores of incision at rest;NRS pain scores of incision during neck movement; | — |
Countries
China
Contacts
Public ContactFang Zhong
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed