Correlation between serum chi3l1 and postoperative cognitive dysfunction in the elderly

Status

Recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2100048826

Enrollment

Unknown

Registered

2021-07-18

Start date

2021-10-01

Completion date

Unknown

Last updated

2022-05-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

postoperative cognitive dysfunction

Interventions

case group:Nil

Eligibility

Sex/Gender

All

Age

65 Years to 100 Years

Inclusion criteria

Inclusion criteria: 1. Aged over 65 years; 2. Patients scheduled for hip replacement surgery.

Exclusion criteria

Exclusion criteria: 1. American Society of anesthesiologists (ASA) physical condition >=IV; 2. The preoperative Mini Mental State Assessment Scale (MMSE) scored illiteracy (uneducated) 6 years) <=24 points; 3. They have a history of dementia, schizophrenia, Parkinson's disease, cerebrovascular disease, recent stroke and other mental disorders; 4. A history of severe anxiety, long-term use of opioids or other psychotropic substances; 5. Dialysis dependent renal failure and liver transaminase were 1.5 times higher than normal; 6. Severe hearing or visual impairment.

Design outcomes

Secondary

Measure	Time frame
PSQI;amount of bleeding;extubation time;hospital stays;	—

Primary

Measure	Time frame
mini mental status examination;Montreal Cognitive Assessment ;CHI3L1 protein;IL-1ß;IL-6;C-reactive protein;	—

Countries

China

Contacts

Public ContactWangZiping

Affiliated Hospital of Xuzhou Medical University

zhpsqxt@163.com+86 18020566899

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026