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A multicenter randomized controlled trial of edaravone and dexcamphan on the effect of blood-brain barrier repairment in acute large vessel occlusive cerebral infarction of anterior circulation

A multicenter randomized controlled trial of edaravone and dexcamphan on the effect of blood-brain barrier repairment in acute large vessel occlusive cerebral infarction of anterior circulation

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2100048812
Enrollment
Unknown
Registered
2021-07-16
Start date
2021-10-01
Completion date
Unknown
Last updated
2022-03-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute cerebral arterial thrombosis

Interventions

control group:Edaravone injection 30mg bid ivdrip in the treatment of 12 cases ± 2 days
experimental group:Edaravone and dextromethor injection 30mg / 7.5mg bid ivdrip in the treatment of 12 cases ± 2 days

Sponsors

Provincial Hospital Affiliated to Shandong First Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
35 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Patients with acute ischemic stroke within 2-48 hours of onset; 2. TOAST classification considered large artery atherosclerosis; 3. Aged 35-80 years old; 4. NIHSS 4 to 24; 5. Sign informed consent.

Exclusion criteria

Exclusion criteria: 1.Patients with cerebral hemorrhage or infarction hemorrhage transformation at the time of onset; 2.He had a history of cerebral infarction in the past six months; 3.Claustrophobia or other reasons can not cooperate with the completion of MRI patients; 4.Patients who participated in other clinical trials or could not comply with the study protocol for other reasons.

Design outcomes

Primary

MeasureTime frame
NIHSS score;MRS score;

Secondary

MeasureTime frame
New infarction;

Countries

China

Contacts

Public ContactSun Qinjian

Provincial Hospital Affiliated to Shandong First Medical University

sqj1210@163.com+86 15168885366

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026