non-small cell lung cancer
Conditions
Interventions
Sponsors
Peking University Third Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age >=18 years old, life expectancy is more than 12 weeks; 2. Locally advanced or metastatic non-small cell lung cancer: either newly treated or previously treated patients can be used, of which the treated patients need to have used <= 1 chemotherapy regimen; 3. Have at least 1 measurable target lesion according to RECIST1.1 criteria; 4. Requirements for driver gene status: regardless of whether there is a known driver gene mutation; patients with unknown genetic status should undergo genetic testing by a designated laboratory. 5. Specimen requirements: there are lesions that are convenient for needle biopsy, fresh specimens with sufficient cell culture can be obtained, and needle biopsy has been planned in routine diagnosis and treatment. Pulmonary primary tumor is preferred, malignant pleural effusion, superficial lymph node, subcutaneous metastasis, intrapulmonary metastasis, liver metastasis, etc. can also be selected; 6. Physical fitness score: ECOG 0-2 points, which can be relaxed to 3 points for patients who plan to use targeted drug monotherapy; 7. The functional reserve of each organ is sufficient; 8. Active anti-tumor therapy will be carried out; 9. Subjects (or their legal representatives) understand and voluntarily sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Received >=3 lines of antitumor therapy in the past; 2. Sufficient fresh specimens that cannot be provided; 3. Patients who do not receive active anti-tumor therapy due to various reasons and only palliatively receive symptomatic treatment; 4. The patient has uncontrollable comorbidities, including but not limited to: symptomatic congestive heart failure, unstable angina pectoris and myocardial infarction, uncontrolled grade III hypertension, hepatic insufficiency, renal insufficiency, diabetes, uncontrolled blood sugar , arrhythmia, mental illness or social condition, etc.; 5. Have infectious diseases, including but not limited to hepatitis B virus carriers, hepatitis C, syphilis, HIV, etc.; 6. Women who are pregnant or breastfeeding.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| consistancy; | — |
Countries
China
Contacts
Public ContactCao Baoshan
Peking University Third Hospital
Outcome results
None listed