myasthenia gravis
Conditions
Interventions
Experimental group:Famciclovir antiviral treatment during perioperative period
Control group:No
Sponsors
Tianjin Medical University affiliated General Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. At the research center, patients with myasthenia gravis (MG) are diagnosed in accordance with the diagnostic criteria of the 2015 Chinese Myasthenia Gravis Diagnosis and Treatment Guidelines as assessed by neurologists; 2. On the basis of typical clinical features of MG, with pharmacological and/or neuroelectrophysiological features, excluding other diagnoses, MG can be diagnosed clinically. 3. Thymus imaging (CT and MR) consider thymus hyperplasia; 4. From July 2021 to July 2022, receive basic treatment and randomized antiviral/placebo treatment (cholinesterase inhibitors, adrenal cortex hormones, etc.) at the Thoracic Surgery Department of the Research Center; 5. Subjects voluntarily join the study, agree to collect relevant information including hematology test information, and sign an informed consent form (patients under the age of 18 are signed by their legal representatives).
Exclusion criteria
Exclusion criteria: 1. Accompanied by serious underlying diseases, such as liver and kidney failure, heart failure, etc.; 2. Patients with other systemic tumors; 3. Evaluation of the prognosis of the impact of mental illness; 4. According to the judgment of the investigator, there are other patients with concomitant diseases that seriously endanger the safety of the patient or affect the completion of the study; 5. The investigator assesses those who are expected to have poor compliance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| time-weighted averaged Quantitative Myasthenia Gravis score;time-weighted average required dose of prednisone;immunizational funtional test;Flow cytometry; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hospitalization time due to myasthenia gravis within 3 years after enrollment (days);Myasthenia gravis activity of daily living score;Proportion of participants who reached the lowest performance status;Whether to use non-glucocorticoid immunosuppressive agents, plasma exchange, intravenous use of gamma globulin; | — |
Countries
China
Contacts
Public ContactZhang Peng
Tianjin Medical University affliated General Hospital
Outcome results
None listed