Efficacy and safety of esketamine for postoperative analgesia in patients undergoing gneral anesthesia: prospecitve, randomized, double-blind, clinical trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100048781

Enrollment

Unknown

Registered

2021-07-16

Start date

2021-08-01

Completion date

Unknown

Last updated

2022-03-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain

Interventions

Control group:Blank

Group 1:High dose Esketamine

Group 2:Low dose Esketamine

Eligibility

Sex/Gender

Male

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1. General anesthesia for abdominal surgery, age 18 to 60 years old, no gender restrictions; 2. ASA classification: I to II, patients who have not used analgesics, muscle relaxants or sedatives within 24 hours before surgery, and are expected to need more than 24 hours of postoperative pain relief.

Exclusion criteria

Exclusion criteria: 1. History of chronic pain; 2. Long-term use of analgesics or psychotropic drugs (such as opioid analgesics, non-steroidal anti-inflammatory drugs, sedatives, anti-inflammatory drugs); history of alcohol abuse; pregnancy or lactation; patients with verbal communication disorders.

Design outcomes

Primary

Measure	Time frame
visual analogue scale;	—

Countries

China

Contacts

Public ContactFeng Aimin

Henan Cancer Hospital

fengaiminhappy@163.com+86 13939079573

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026