Adverse reactions related to narcotic drugs
Conditions
Interventions
Normal Saline control group:Pretreatment with equal amount of normal saline
10µg/kg butorphanol experiment group:Pretreatment with 10µg/kg butorphanol
10µg/kg butorphanol experiment group:Pretreatment with 20µg/kg butorphanol
Sponsors
Hunan Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 65 years; 2. For patients undergoing elective general anesthesia abdominal laparoscopic surgery requiring postoperative analgesia pump, the estimated operation time 1-4 hours; 3. ASA score I-III; 4. 18.5kg/m2<BMI<30kg/m2; 5. Clearly understand and voluntarily participate in the research, and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Opioid-tolerant patients; 2. Patients who are dependent on narcotine; 3. Pregnant and lactating women; 4. Unable to cooperate due to mental illness or other reasons; 5. Patients with central nervous system disease before surgery; 6. History of chronic pain (pain symptoms for more than 3 months); 7. Patients taking sedatives, antidepressants or drugs that excite the central nervous system before surgery; 8. Alcoholism; 9. Patients with bronchial asthma or chronic obstructive pulmonary disease before surgery; 10. Patients who have taken steroids and bronchodilators in the past two weeks; 11. Patients with upper respiratory tract infection in the past two weeks 12. Past history of PONV or motion sickness 13. Patients with myocardial infarction, ventricular dysfunction, and coronary insufficiency; 14. Participate in other drug clinical investigators within the past three months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of cough; | — |
Secondary
| Measure | Time frame |
|---|---|
| Severity of cough occurrence;Vital signs;Intraoperative blood loss;Blood transfusion Volume;Rehydration fluids;??;Wake-up quality;Ramsay sedation score;Agitation score;Postoperative nausea and vomiting score;VAS score;Adverse reactions; | — |
Countries
China
Contacts
Public ContactKong Gaoyin
Hunan Provincial People's Hospital
Outcome results
None listed