Non-alcholic fatty liver with diabetes mellitus
Conditions
Interventions
Observation group:drug
Control group:life style
Sponsors
Tongji Hospital, Tongji Medical College, Huazhong University ofScience and Technology
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Type 2 diabetes; 2. Aged 18-70 years old; 3. BMI>24kg/m2; 4. B-ultrasound diagnosis of NAFLD; 5. The hypoglycemic drugs for type 2 diabetes have not changed in the past 4 weeks; 6. Have not participated in other clinical observation projects and other weight loss drug interventions in the past 3 months; 7. Glycated hemoglobin is between 7-9% (including upper and lower limits); 8. The lipid-lowering drugs and antihypertensive drugs used in combination in the past 3 months have not been adjusted.
Exclusion criteria
Exclusion criteria: 1. History of heavy drinking (female>20 g/day or male>30 g/day); 2. Liver disease caused by viral hepatitis or other causes; 3. Transaminases exceeding 2.5 times the upper limit of normal; 4. The currently used hypoglycemic drugs include TZD and VitE; 5. History of acute and chronic pancreatitis or thyroid tumor; 6. Use of drugs that may cause weight gain in the past 3 months: such as glucocorticoid therapy, antipsychotic or antidepressant drugs; 7. Have a history of bariatric surgery; 8. History of weight change >5% in the past 3 months; 9. Have used weight loss drugs or GLP-1 drugs in the past 3 months; 10. Other unsuitable conditions: persons with poor cardiopulmonary and renal function; clear history of mental illness; history of allergy to experimental drugs and any components, or other GLP-1 drugs; ? breastfeeding or pregnant women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| height;weight;waist circumference;hips;blood pressure;B ultrasound;Abdominal MRI; | — |
Countries
China
Contacts
Public ContactXIE JUN HUI
Tongji Hospital, Tongji Medical College, Huazhong University ofScience and Technology
Outcome results
None listed