Multiple myeloma
Conditions
Interventions
therapy group A:The dose of PEG-IFN a-2b was 90 µ g, subcutaneously injected for 28 days, once a week, 1-2 times per course, and the researchers adjusted the times of administration according to the t
therapy group B:The dose of lenalidomide is 10mg / 25mg, orally, one course of treatment for 28 days, each course of treatment for 21 days
maintenance therapy lasts at least 6 courses, which can be judged by the researchers to increase the course of maintenance therapy.
Sponsors
Henan Cancer Hospital
Eligibility
Sex/Gender
Male
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. MM newly diagnosed patients or patients who enter maintenance therapy after consolidation therapy (including chemotherapy or transplantation), MRD positive, and curative effect >= PR; 2. ISS staging is medium and high risk patients; 3. Aged 18 to 70 years old; 4. Never used interferon therapy before; 5.ECOG=1.0x10^9/L, PLT>=50x10^9/L; 7. Serum creatinine <2.0 mg/dL, serum bilirubin <=2 times the upper limit of normal; 8. Subjects signed informed consent voluntarily.
Exclusion criteria
Exclusion criteria: 1. Hypersensitivity to active ingredients, alpha-interferon or any excipients of this product; 2. Autoimmune chronic hepatitis; 3. Severe liver dysfunction or decompensated cirrhosis; 4. History of serious heart disease, including unstable or uncontrolled heart disease within 6 months; 5. Have severe mental illness or a history of serious mental illness, mainly depression; 6. Pregnant women or women planning to become pregnant and breastfeeding, or men with childbearing plans; 7. Severe kidney disease (on hemodialysis), epilepsy (needs antispasmodic treatment); 8. History of other malignant tumors within three years; 9. Systemic infection (such as HBV/HCV or HIV, etc.); 10. Those who are judged by the investigator to be unsuitable to participate in this clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The level of MRD decreased in patients.; | — |
Countries
China
Contacts
Public ContactFang Baijun
Henan Cancer Hospital
Outcome results
None listed