Ocular Graft-versus-Host Disease
Conditions
Interventions
Group 1:Lipiflow and meibomian gland massage
Group 2:meibomian gland massage
Sponsors
Zhongshan Ophthalmic Center, Sun Yat-Sen University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Patients after hematopoietic stem cell transplantation, diagnosed with chronic ocular graft-versus-host disease; 2. Aged 18-60 years old; 2. Meet the diagnostic criteria of MGD and have ocular symptoms (OSDI>=13 points or SPEED.=8 points); 3. Participate voluntarily and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Those with contraindications to thermal pulse therapy (such as abnormal eyelid structure, etc.); 2. The systemic condition is unstable or there are other complications; 3. Those who are allergic to sodium fluorescein; 4. Those who are pregnant or breastfeeding or planning to become pregnant in the near future; 5. Have undergone ophthalmic surgery or have a history of eye trauma in the past 6 months; 6. History of systemic medication of drugs that may cause dry eye and meibomian gland dysfunction (such as antihistamines, antidepressants, etc.) 3 months before enrollment; 7. Patients with neuropsychiatric diseases; 8. The researcher believes that there are any reasons why they are not suitable to participate in the experiment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Questionnaires; | — |
Secondary
| Measure | Time frame |
|---|---|
| Tear film assessment;Slit lamp examination;visual acuity;visual quality;Intraocular pressure;adverse events; | — |
Countries
China
Contacts
Public ContactLiang Lingyi
Zhongshan Ophthalmic Center, Sun Yat-Sen University
Outcome results
None listed