FindTrial
Sign In

Clinical significance of expression of HIF-1/BNIP3 signaling pathway in children with traumatic brain injury and intervention of Metformin

Clinical significance of expression of HIF-1/BNIP3 signaling pathway in children with traumatic brain injury and intervention of Metformin

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2100048753
Enrollment
Unknown
Registered
2021-07-16
Start date
2021-07-26
Completion date
Unknown
Last updated
2022-03-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

traumatic brain injury

Interventions

MET group / Conventional treatment group:metformin

Sponsors

Xuzhou Children's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
0.5 Years to 16 Years

Inclusion criteria

Inclusion criteria: 1. Have a clear history of traumatic brain injury, confirmed as TBI by head CT scan or magnetic resonance imaging (MRI) examination; 2. The time from injury to admission is less than 24 hours; 3. No previous neurological disease and brain trauma; 4. No other serious organic disease; 5. Informed consent of the children's parents.

Exclusion criteria

Exclusion criteria: 1. Have underlying diseases such as autoimmune diseases, blood diseases, endocrine diseases or malignant tumors; 2. Parents withdrew from the study halfway through.

Design outcomes

Primary

MeasureTime frame
mortality rate;Glasgow Coma Index Score;National Institutes of Health Stroke Scale Score;Glasgow Prognostic Score;—

Secondary

MeasureTime frame
protein S100B;neuron-specific enolase;Hypoxia-inducible factor-1a;Bcl-2/Adenovirus E1B19kDa-related protein 3;IL-1ß;IL-6;TNF-a;protein Smac;caspase activator 1;caspase-3 protease;Beclin-1;P62;Cyt-C;—

Countries

China

Contacts

Public ContactZhu Lei

Xuzhou Children's Hospital

xuzhouzhulei317@163.com+86 13685134366

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026