MOG-IgG associated disease
Conditions
Interventions
azathiopurine group:azathiopurine
mortimecofenate group:mortimecofenate
gamma globulin group:gamma globulin
Sponsors
Department of Pediatrics, Peking University First Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age of onset = 2 clinical attacks in the course of the disease, and at least 1 recurrence within the past 1 year or at least 2 recurrences within 2 years; 4. Use mycophenolate mofetil, azathioprine, rituximab or intravenous gamma globulin to prevent recurrence, and the application time is <=3 months; 5. No other immunosuppressive drugs (excluding glucocorticoids) have been used in the past.
Exclusion criteria
Exclusion criteria: 1. Suffering from other autoimmune diseases (such as Sj?gren's syndrome, systemic lupus erythematosus, etc.); 2. Combined with autoimmune encephalitis-related antibodies; 3. Suffer from systemic bacterial, viral or fungal infection; 4. Suffering from malignant tumor or previous history of malignant tumor; 5. Liver insufficiency (ALT > 3 times the upper limit of normal or AST > 3 times the upper limit of normal); 6. Renal insufficiency (GFR<60ml/min); 7. Hematological diseases (Hb<60g/L, PLT<50x10^9/L, N<1x10^9/L, L<0.8x10^9/L); 8. Patients who cannot undergo MRI scans.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 2 year relapse rate; | — |
Countries
China
Contacts
Public ContactWu Ye
Department of Pediatrics, Peking University First Hospital
Outcome results
None listed