Depression
Conditions
Interventions
Group 1:Antidepressant
Group 2:Mood stabilizer
Sponsors
Beijing Anding Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
16 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. The brief international neuropsychiatric interview (MINI) version is used for evaluation, which meets the diagnostic criteria for major depressive disorder, and both single depressive episode and recurrent depressive disorder are acceptable; 2. Using DSM-5 assessment, meet the diagnostic criteria for depressive episodes with mixed features; 3. Hamilton 17-item depression scale (HAMD-17) >= 17 points; 4. Aged 16 to 60 years old, both outpatient and inpatient; 5. Patients voluntarily participated in the study and signed a written informed consent.
Exclusion criteria
Exclusion criteria: 1. Those who meet the diagnosis of bipolar disorder, schizophrenia, other psychotic disorders, personality disorders or mental retardation; 2. Those who have a history of substance abuse or dependence in the 12 months before enrollment; 3. Those with obvious suicidal tendencies or HAMD-17 item 3 (suicide item) score >= 3; 4. Those with severe and unstable physical diseases; 5. Those who are allergic to or ineffective to the study drug (sodium valproate or escitalopram oxalate) in the past; 6. Women who are pregnant or breastfeeding, or who plan to become pregnant, or who do not agree to use contraception; 7. Those who have received electroconvulsive therapy within 1 month before enrollment; 8. Participated in another interventional clinical investigator in the past year.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Patient Health Questionnare, PHQ-9;Generalized Anxiety Disorder, GAD-7;Hypomania Check List, HCL-33;Snaith-Hamilton Pleasure Scale, SHAPS;Sheehan Disability Scale, SDS;Side Effects Scale;Morisky Medication Adherence Scale, MMAS;Hamilton Depression Rating Scale for Depression -17-item, HAMD-17;Hamilton Depression Rating Scale for Anxiety, HAMA;Young Mania Rating Scale, YMRS;Non-Suicidal Self-Injury Behavior Inventory, NSSI;Columbia Suicide Scale;Drug concentration;Complete remission rate; | — |
Countries
China
Contacts
Public ContactWang Xue
Beijing Anding Hospital, Capital Medical University
Outcome results
None listed