Advanced malignant solid tumor
Conditions
Interventions
Intervention group:High flavonoid content fruit and vegetable diet guidance
Control group:No
Sponsors
Xiang'an Hospital of Xiamen University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Patients diagnosed as advanced malignant solid tumor with definite pathological and CT imaging evidence; 2.F&V diets are below the average of 4.4 servings per day; 3.Male or female, age 18 ~80 years old; 4.Karnofsky score >=60; 5.Expected survival >=3 months; 6.Subjects must give informed consent to the study before the study and voluntarily sign a written informed consent, which shows good compliance; 7.The major organs are functioning normally.
Exclusion criteria
Exclusion criteria: 1. Have taken antibiotics within 5 weeks before enrollment; 2. Use of probiotic and/or prebiotic supplements and/or complementary foods before enrollment and throughout the study (=3 times/week); 3. Patients who received other study drugs within 30 days before randomization; 4. Receive psychotropic drug treatment (antidepressants, anti-anxiety drugs, anti-manic drugs, etc.) within 3 months before enrollment; 5. Patients who have received systemic corticosteroids (prednisone>10mg/day or equivalent doses of similar drugs) or other immunosuppressive drugs within 14 days before enrollment, except for the following patients: using topical, eye, joint Intracavitary, intranasal, and inhaled corticosteroid therapy; short-term corticosteroid prophylaxis (eg, docetaxel prophylaxis, contrast hypersensitivity); 6. Cognitive and communication barriers; 7. Female patients are pregnant or breastfeeding; 8. The investigator believes that there are any other conditions that may adversely affect the participant's compliance or indicator measurement in completing the study, or any other situation that may pose a significant risk to the participant.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Flavonoid markers;Salivary cortisol;Blood cortisol;Gut microbiota;Mental Health Assessment Questionnaire;Fecal short chain fatty acids;Changes in defecation habits and traits; | — |
Secondary
| Measure | Time frame |
|---|---|
| Immune cells and cytokines; | — |
Countries
China
Contacts
Public ContactKang Xinmei
Department of Oncology, Xiang'an Hospital of Xiamen University, Xiamen University
Outcome results
None listed