Hypotension during gastrointestinal surgery in elderly patients
Conditions
Interventions
experimental group:esketamine
Sponsors
The First Affiliated Hospital of Xi'an Jiaotong University
Eligibility
Sex/Gender
All
Age
65 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Aged 65 to 90 years, gender is not limited; 2. Patients who plan to undergo elective laparoscopic gastrointestinal surgery under general anesthesia, the expected duration of the surgery is more than 2 hours; 3. ASA score is I~III; 4. Voluntarily participate in this clinical trial and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Preoperative visit blood pressure >=180/110 mm Hg (WHO-ISH hypertension guideline grade 3 hypertension); 2. Those with serious risk of increased intracranial pressure, such as intracranial tumor, intracranial infection, intracranial hemorrhage, etc.; 3. Severe liver and kidney dysfunction; 4. Those who have contraindications or allergies to experimental drugs and other anesthetic drugs; 5. Untreated or poorly controlled hyperthyroidism; 6. Patients with high intraocular pressure such as glaucoma; 7. Those who are taking reserpine; 8. Patients with severe impairment of auditory, visual and language system functions who cannot cooperate with the investigator's visit; 9. Confirmed/suspected of abuse or long-term use of narcotic sedative analgesics; Patients enrolled in other studies within 10.30 days.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of IOH(Intraoperative hypotension); | — |
Secondary
| Measure | Time frame |
|---|---|
| Cumulative time of IOH;Cumulative dose of vasopressors;The postoperative recovery quality of patients;Incidence of postoperative pain, nausea and vomiting;Postoperative outcomes of the patient; | — |
Countries
China
Contacts
Public ContactWang Qiang
The First Affiliated Hospital of Xi'an Jiaotong University
Outcome results
None listed