Suspected or confirmed infection by methicillin-resistant staphylococcus aureus
Conditions
Interventions
Case series:N/A
Sponsors
None listed
Eligibility
Sex/Gender
Male
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: (1) At least 18 years old; (2) Admitted to one of the following hospitals under Hospital Authority: Pamela Youde Nethersole Eastern Hospital, Ruttonjee and Tang Shiu Kin Hospitals, Queen Mary Hospital, Queen Elizabeth Hospital, Kwong Wah Hospital, United Christian Hospital, Prince of Wales Hospital, Princess Margaret Hospital, or Tuen Mun Hospital; and (3) prescribed intermittent intravenous vancomycin.
Exclusion criteria
Exclusion criteria: (1) Documented trypanophobia or hemophobia; (2) Subjects prescribed any form of renal replacement therapy to be started before or during IV vancomycin treatment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Good predictive performance and stability of the developed popPK model;Proportion of subjects achieving the PK therapeutic target at any time point during treatment;Reduced proportion of subjects developing acute kidney injury; | — |
Secondary
| Measure | Time frame |
|---|---|
| Shortened time to achieving the pharmacokinetic therapeutic target;Shortened time to becoming afebrile;Shortened time to normalized white blood cell counts;Shortened duration of antibiotic treatment;Number of measurements of serum vancomycin concentration; | — |
Countries
China
Contacts
Public ContactLAM Tai Ning Teddy
School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong
Outcome results
None listed