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Research on the expression of PGRMC1 in patients with PCOS and the related molecular mechanism

Research on the expression of PGRMC1 in of patients with PCOS and the related molecular mechanism

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2100048684
Enrollment
Unknown
Registered
2021-07-12
Start date
2021-08-01
Completion date
Unknown
Last updated
2022-03-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

polycystic ovary syndrome

Interventions

Control group:None

Sponsors

Guangdong Women and Children Hospital
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 35 Years

Inclusion criteria

Inclusion criteria: PCOS group: 1.Accord with Rotterdam diagnostic criteria; 2.Aged 18 to 35 years; 3.Volunteer to participate in the study and sign the informed consent. Control group: 1.Patients without endocrine disease history and have normal menstruation; 2.Aged 18 to 35 years; 3.Informed consent, voluntary participation and good compliance.

Exclusion criteria

Exclusion criteria: 1.Complicated with cardiovascular and cerebrovascular diseases, liver and kidney diseases, thrombus diseases and other serious primary diseases; 2.Alcohol, smoking or drug addiction; 3.With ovarian malignant tumor; 4.With unexplained infertility; 5.With thyroid disease, hyperprolactinemia, Cushing syndrome and other endocrine diseases; 6.Premature luteinization of follicles and early onset of LH peak during the ovulation induction cycle.

Design outcomes

Primary

MeasureTime frame
The expression of PGRMC1 in ovarian tissue;The expression of PGRMC1 in ovarian granulosa cells;The expression of PGRMC1 in the follicular fluid;The expression of PGRMC1 in the serum;

Secondary

MeasureTime frame
Glucolipid metabolism hormone;Sex hormone;

Countries

China

Contacts

Public ContactLi Li

Guangdong Women and Children Hospital

lili-1406@163.com+86 13631446859

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026