Effect of early fluid resuscitation based on sodium bicarbonate Ringer's solution on renal function and tissue perfusion in patients with sepsis

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100048673

Enrollment

Unknown

Registered

2021-07-12

Start date

2021-08-01

Completion date

Unknown

Last updated

2022-03-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients with sepsis

Interventions

Two groups:Liquid resuscitation was performed with 30ml/ kg sodium bicarbonate Ringer's solution within the initial 3 hours

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1.Aged >=18 years old; 2.Meet the sepsis diagnostic criteria in the 2018 Guidelines for the Diagnosis and Treatment of Severe Sepsis and Septic Shock; 3.Sign the informed consent.

Exclusion criteria

Exclusion criteria: 1.Other causes of shock; 2.Hypermagnesemia; 3.Hypothyroidism; 4.Complicated with chronic organ failure; 5.Patients in palliative care; 6.Pregnant or lactation.

Design outcomes

Primary

Measure	Time frame
Lactic acid clearance;Renal interlobar artery resistance index;	—

Countries

China

Contacts

Public ContactLi Yong

Cangzhou Central Hospital, Hebei Province

ly13333367871@hotmail.com+86 13333367871

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026