bullous keratopathy
Conditions
Interventions
Test group :Heterogenous corneal endothelial transplantation
Sponsors
Beijing Tongren Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
50 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Clinical diagnosis of bullous keratopathy, patient with ocular pain as the main complaint, visual acuity as no light perception, and intraocular pressure <= 21 mmHg (measured by rebound tonometer) and stable; 2.Age 50 years or older, gender not limited; 3.Signed written informed consent, voluntary participation in the study, and good compliance.
Exclusion criteria
Exclusion criteria: 1.Patients with a history of serious cardiovascular, hepatic, renal, and other systemic diseases; 2.Patients with infectious diseases (including but not limited to: hepatitis B, hepatitis C, syphilis, acquired immunodeficiency syndrome); 3.Patients with a history of malignant blood disorders; 4.Patients with a history of malignant neoplasm; 5.History of allergy; 6.Premenopausal women or subjects with childbirth plans; 7.Adults diagnosed as mentally retarded or mentally incapacitated; 8.Patients who are severely depressed, anxious or otherwise considered psychologically inappropriate for this study; 9.Subjects who are otherwise considered by the study physician to be inappropriate for enrollment in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Restoration of corneal transparency; | — |
Secondary
| Measure | Time frame |
|---|---|
| The degree to which perceived eye discomfort (e.g. pain) is relieved;Corneal endoscopy and in vivo confocal microscopy showed normal number and morphology of endothelial cells;Optical coherence tomography showed that corneal thickness reached normal range (central thickness 600-750 µm); | — |
Countries
China
Contacts
Public ContactPan Zhiqiang
Beijing Tongren Hospital, Capital Medical University
Outcome results
None listed