Orthopedic surgery
Conditions
Interventions
S group:During the perioperative period, the same amount of normal saline was injected intravenously, and the automatic analgesic pump was routinely used after operation
K1 group:After induction of general anesthesia, a single injection of 0.25mg/kg esticketamine was given intravenously, followed by continuous injection of 0.12mg/kg/h esticketamine until the end of su
K2 group:After induction of general anesthesia, a single injection of 0.25mg/kg esticketamine was given intravenously, followed by continuous injection of 0.12mg/kg esticketamine until the end of surg
Sponsors
The First Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
All
Age
45 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Patients scheduled for orthopedic surgery ; 2.Patients with ASA grade I-III; 3.Patients aged 45 to 75 years; 4.Patients with body mass index (BMI) < 30; 5.Patients willing to sign informed consent of anesthesia.
Exclusion criteria
Exclusion criteria: 1.Patients with bone tumor; 2.Patients who are allergic to the study drug; 3.Patients with severe hypertension and liver and kidney dysfunction; 4.Patients with long-term opioid use, alcohol or drug abuse; 5.Patients with consciousness disorder or severe mental and nervous system diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| visual analogue scale;Patient characteristics, operation duration, anesthetic dosage, and intraoperative vital signs;use of automatic analgesia pump;self rapid assessment scale for depression and Generalized Anxiety Disorder Scale scores;pain status, recovery status, neuropathic pain assessment scale;[lasma inflammatory factor levels; | — |
Secondary
| Measure | Time frame |
|---|---|
| wound infection, time to get out of bed, time to leave hospital;the occurrence and severity of adverse reactions caused by anesthetic related drugs; | — |
Countries
China
Contacts
Public ContactAi Yanqiu
The First Affiliated Hospital of Zhengzhou University
Outcome results
None listed