Stroke
Conditions
Interventions
Experimental group:Hand - speech synchronization training
Control group:Hand function and language function were trained conventionally respectively
Sponsors
Huashan Hospital, Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Patients with cerebral infarction / cerebral hemorrhage in the left hemisphere for the first time confirmed by head computed tomography (CT) or magnetic resonance (MRI) (the diagnosis is in line with the consensus of "key points for the diagnosis of various major cerebrovascular diseases in China 2019" formulated by the cerebrovascular disease group of Neurology branch of Chinese Medical Association); 2.The course of disease was 1-6 months; 3.Brunnstrom stage: hand stage III - V, upper limb stage II - V; Fma-ue score was 8-50; The muscle group above elbow joint was MAS < 2; 4.The AQ was less than 70 by WAB; The mother tongue is Chinese, and the language function is normal before the onset; 5.They were aged 18 to 80 years, with primary school education or above, and were identified as right handers by the standardized questionnaire survey on the distribution of left and right handers in Chinese; 6.The score of non-verbal cognitive function scale is more than 65, which can be used to complete relevant tests; 7.Volunteer to participate in this study and sign informed consent.
Exclusion criteria
Exclusion criteria: 1.Previous history of brain injury, epilepsy, alcohol or drug dependence and other diseases that may affect brain function and structure; 2.Combined with chronic infectious diseases; 3.Metal implants (such as pacemaker) and claustrophobia were contraindications of MRI examination; 4.Patients with Alzheimer's disease, Parkinson's disease and other diseases that affect the rehabilitation evaluation; 5.Malignant tumor, bleeding tendency, active tuberculosis, severe cardiopulmonary insufficiency, pregnancy and other intolerance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fugl-Meyer Motor Function Scale;Functional magnetic resonance imaging;Functional near infrared spectroscopy;Western aphasia test; | — |
Secondary
| Measure | Time frame |
|---|---|
| Upper Extremity Motion Research Scale;Modified Barthel index rating scale;Log box obstacle test;Verbal Fluency Test;Neuroelectrophysiological indicators related to transcranial magnetic stimulation;Boston Naming Test; | — |
Countries
China
Contacts
Public ContactXu Shuo
Huashan Hospital, Fudan University
Outcome results
None listed