novel coronavirus pneumonia (COVID-19)
Conditions
Interventions
Morning group:Vaccinated the third dose of COVID-19 inactivated vaccine in the morning
Afternoon group:Vaccinated the third dose of COVID-19 inactivated vaccine in the afternoon
Sponsors
the First Affiliated Hospital, Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
18 Years to 59 Years
Inclusion criteria
Inclusion criteria: 1.Aged 18 to 59 years; 2.Participants who had finished two dose of inactivated vaccine against Novel Coronavirus of Beijing biological vaccine.
Exclusion criteria
Exclusion criteria: 1.Patients are allergic to any component of the vaccine, and those who have history of severe allergic reactions to the vaccine, such as acute allergic reactions, urticaria, skin eczema, dyspnea, angioedema or abdominal pain; 2.Patients with fever, acute disease, severe chronic disease or acute onset of chronic disease; 3.Pregnant women, lactating women, or having a pregnancy plan within 3 months; 4.Patients with a history or family history of convulsions, epilepsy, encephalopathy or mental illness; Patients with uncontrolled epilepsy and other progressive neurological diseases; Patients with a history of Guillain-Barré syndrome; 5.Has been diagnosed with congenital or acquired immune deficiency, HIV infection, lymphoma, leukemia or other autoimmune disease; 6.Known or suspected suffering from serious respiratory diseases, serious cardiovascular diseases, liver and kidney diseases, malignant tumors; 7.A history of COVID-19 infection; 8.Patients who take medicine affecting the immune function, such as immunosuppressant agents or immunopotentiators or glucocorticoids (>=10mg prednisone or other equivalent glucocorticoids) within one month before enrollment; 9.Patients are considered unsuitable for vaccination by clinicians.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Novel Coronavirus receptor binding domain specific antibody levels; | — |
Secondary
| Measure | Time frame |
|---|---|
| Immunocell phenotype;Adverse reaction; | — |
Countries
China
Contacts
Public ContactPeng Sui
the First Affiliated Hospital, Sun Yat-sen University
Outcome results
None listed