Depressive Disorder, Bipolar Disorder
Conditions
Interventions
Gold Standard:Hamilton Depression Scale 17 items, Young's Manic Scale, DSM-5, M.I.N.I scale.
Neurogenic 
were 
isolated 
and 
sequenced
Biomarker: 
neurogenic 
MiSeq.
Sponsors
Shanghai Mental Health Center
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for uniphasic depression : 1.Subjects voluntarily signed informed consent; 2.Aged 18 to 60 years, regardless of gender; 3.Meets the diagnostic criteria for a DSM-5 major depressive episode; 4.Patients with recurrent clinical depression, the number of previous depressive episodes >=2; 5.The total score of 17 items on the Milton Depression Scale (HAMD17) is >=17 points; 6.Sufficient audio-visual proficiency to carry out the necessary examinations for the study; 7.No drug use within 3 months prior to recruitment (generally 3-5 drug half-life). Inclusion criteria for bipolar depressive episode: 1.Subjects voluntarily signed informed consent; 2.Aged 18 to 60 years, regardless of gender; 3.Meets the diagnostic criteria for DSM-5 bipolar disorder BD-II; 4.A current or recent episode of depression; 5.The total score of 17 items in the Hamilton Depression Scale (HAMD17) was >=17, and the total score of Young's Mania Scale (YRMS) was <6; 6.No drug use within 3 months prior to recruitment (generally 3-5 drug half-life); 7.Sufficient audio-visual proficiency to carry out the necessary examinations for the study. Inclusion criteria for healthy subjects were : 1.The M.I.N.I scale and the assessment at admission did not meet any of the DSM-5 diagnostic criteria; 2.A total score of 17 items on the Hamilton Depression Scale (HAMD17) <=7; 3.No history of major medical or mental illness; No family history of mental illness. 4.Sufficient audio-visual proficiency to carry out the necessary examinations for the study; 5.Subjects voluntarily sign the informed consent.
Exclusion criteria
Exclusion criteria: 1.Schizophrenia or schizoaffective disorder meeting DSM-5 diagnostic criteria; 2.Patients with serious surgical or physical diseases (such as cancer, kidney dialysis, etc.), organic brain diseases, neurological diseases or mental retardation; 3.Abuse or dependence of comorbidities; 4.Pregnant or lactating women; 5.Uncooperative or difficult to complete the scale evaluation; 6.Severe suicide attempt (HAMD-17, item 3, "suicide" score >=3); 7.Patients who had received electroconvulsive therapy in the past month.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 17 items on the Milton Depression Scale;Young Mania Rating Scale;Concise International Neuropsychiatric Interview Scale;Diagnostic and Statistical Manual of Mental Disorders (Fifth edition) scale; | — |
Countries
China
Contacts
Public ContactZhang Chen
Outcome results
None listed