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To compare the effect of propofol and alfentanil on postoperative cognitive function of patients undergoing colonoscopy

To compare the effect of propofol and alfentanil on postoperative cognitive function of patients undergoing colonoscopy

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2100048639
Enrollment
Unknown
Registered
2021-07-12
Start date
2021-07-08
Completion date
Unknown
Last updated
2022-03-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Outpatient anesthesia

Interventions

Propofol group:2mg/kg propofol
alfentanil group:10ug/kg alfentanil
Blank control group:

Sponsors

Department of Anesthesiology, The Second Affiliated Hospital of Chongqing Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Aged 18 to 65 years; 2. ASA grade I~III, the preoperative MMSE score of patients undergoing elective surgery was >=24; 3. Patients requiring enteroscopy under intravenous anesthesia; 4. No history of allergy to narcotic drugs; 5. Agree to participate in the study and sign the informed consent.

Exclusion criteria

Exclusion criteria: 1. Patients with preoperative mental illness or lack of communication ability, cognitive impairment or unable to cooperate with the completion of the preoperative assessment; 2. Those who are confirmed or suspected to have abused or used other narcotic sedatives and analgesics and patients with long-term alcoholism; 3. Morbid obesity (body mass index > 30 kg/m2), history of receiving anesthesia within the last 7 days, and known allergies to study drugs or patients with contraindications to propofol and alfentanil; 4. The attending doctor or the researcher believes that there are other circumstances that are not suitable for participating in this study.

Design outcomes

Primary

MeasureTime frame
Cognitive function;

Secondary

MeasureTime frame
Blood pressure;Heart rate;pulse oxygen saturation;Propofol total dosage;Discharge time;

Countries

China

Contacts

Public ContactHuang He

Department of Anesthesiology, The Second Affiliated Hospital of Chongqing Medical University

13708385559@163.com+86 13708385559

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026