Liver failure
Conditions
Interventions
group1:Prospective cohort of liver failure
group2:Prospective cohort of hepatitis B and liver cirrohsis
group 3:Prospective cohort of pre-liver failure
Sponsors
Qilu Hospital of Shandong University
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: 1. Age 18-65 years old, gender is not limited; 2. Meet the diagnostic criteria of the 2018 China Guidelines for the Diagnosis and Treatment of Liver Failure; 3. Laboratory tests: jaundice: serum total bilirubin >= 171 umol/L and coagulation disorders [international normalized ratio (INR) >= 1.5 or prothrombin activity (PTA) < 40%]; 4. Ascites and/or hepatic encephalopathy: confirmed by physical examination; 5. Understand and voluntarily sign the informed consent form approved by the ethics committee; 6. Be able to comply with the research procedures and visit schedule prescribed by the protocol.
Exclusion criteria
Exclusion criteria: 1. Serious diseases of other systems; 2. Patients co-infected with other hepatitis viruses and other non-hepatotropic viruses; 3. Liver cancer patients; 4. Alcohol: history of drinking within 4 weeks; 5. History of taking hepatotoxic drugs and Chinese herbal medicines within 4 weeks; 6. Onset of autoimmune hepatitis or Wilson disease; 7. 3-month medical and surgical history; 8. Unknown liver toxicity factors; 9. There are any other factors that the investigator considers unsuitable for inclusion in this study or completion of the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 3 month mortality; | — |
Countries
China
Contacts
Public ContactFan Yuchen
Qilu Hospital of Shandong University
Outcome results
None listed