Advanced epithelial ovarian cancer
Conditions
Interventions
Surgery Group:A certain degree of cytoreductive surgery with adjuvant chemotherapy
Ccontrol Group:Neoadjuvant chemotherapy with interval debulking surgery
Sponsors
Obstetrics and Gynecology Hospital Affiliated to Fudan University
Eligibility
Sex/Gender
Female
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 70 years; 2. Histopathologically diagnosed as advanced epithelial ovarian cancer; 3. After clinical evaluation, the initial operation cannot reach R0 or R1; 4. Unbearable systemic symptoms such as extreme fatigue, unexplained pain, dyspnea, repeated bleeding, or local symptoms such as obstruction, rupture, and obvious compression due to large tumor burden; laboratory tests show coagulation dysfunction, systemic inflammatory response or cardiac , liver, brain, lung, kidney and other important organ dysfunction; imaging examination showed extensive tumor metastasis; 5. Have not received any surgical treatment related to the disease before this study; 6. Those who have no contraindications to intravenous chemotherapy; 7. Sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with recurrent ovarian cancer; 2. Have received surgical treatment related to the disease; 3. Combined with other malignant diseases; 4. Mental illness or mental illness, unable to cooperate with the experiment; 5. Patients whose family members request to conceal their illness; 6. Participate in other clinical trials at the same time.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Objective response rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mortality at 30 days after surgery;the incidence of perioperative complications;Progression Free Surviva; | — |
Countries
China
Contacts
Public ContactYao Liangqing
Obstetrics and Gynecology Hospital Affiliated to Fudan University
Outcome results
None listed