preterm, SGA, LGA, perinatal brain injury
Conditions
Interventions
preterm group:N/A
Developmental group:N/A
brian injury group:N/A
Sponsors
Peking University First Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. The neonates admitted to the neonatal ward of Peking University First Hospital were divided into 4 groups: A preterm group: 32-36 weeks premature infants, a total of 50 cases; B development group: 50 full-term small-for-gestational age infants Cases, 50 large-for-gestational-age infants; C brain injury group: 50 full-term neonates with clear brain injury; D control group: 100 full-term infants suitable for gestational age; 2. Inclusion criteria for ABD neonates: comprehensive clinical manifestations, physical examination, cranial imaging tests, no evidence of brain injury; 3.C Inclusion criteria for neonates: According to the comprehensive diagnosis of clinical symptoms, signs, cranial imaging (ultrasound, MRI), EEG, etc., including: moderate-severe neonatal hypoxic-ischemic encephalopathy, 3- Grade 4 intracranial hemorrhage, perinatal stroke, bilirubin encephalopathy, neonatal bacterial meningitis, metabolic encephalopathy, etc. Taking the common clinical hypoxic-ischemic brain injury as an example, the acute phase occurs within 72 hours after birth, and the clinical manifestations are changes in consciousness, muscle tone, and primitive reflexes, which may be accompanied by convulsions, and the EEG manifests as background activity. Abnormal, brain imaging showed diffuse cerebral edema.
Exclusion criteria
Exclusion criteria: 1. In the process of near-infrared spectral data acquisition, the subjects were crying and difficult to appease, making the acquisition impossible. 2. The tested neonates had head hematoma. 3. Family members refuse to participate in the research.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| brain network; | — |
Countries
China
Contacts
Public ContactLiu Lili
Beijing University First Hospital
Outcome results
None listed