Hepatocellular carcinoma
Conditions
Interventions
treament group:Radiotherapy(photon) based on "anatomical liver resection"
Sponsors
The Affiliated Tumor Hospital of Fujian Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Pathologically confirmed or in line with the clinical diagnostic criteria for hepatocellular carcinoma. 2. Aged 18 to 75 years, male or female; 3. The tumor is single, the largest diameter is 30x10^9/L; white blood cell count>3x10^9/L or absolute neutrophil value (ANC)>1.5x10^9/L; hemoglobin>90g/L; serum creatinine <2.0 mg/dL; serum alanine aminotransferase and aspartate aminotransferase do not exceed 2.5 times the upper limit of normal; serum total bilirubin does not exceed the upper limit of normal 2 times the limit value; 5. The general condition is good, the ECOG score is 0-2; 6. Sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Intrahepatic spread or extrahepatic metastasis of tumor, portal vein tumor thrombus; 2. Patients with a history of hepatic encephalopathy or ascites in West Haven classification III grade IV; 3. Patients with a history of other malignancies other than primary HCC, except for skin squamous cell carcinoma or basal cell carcinoma; 4. Patients with a history of upper abdominal radiotherapy; 5. In the radiotherapy plan, patients who fail to comply with the radiation dose limitation of vital organs, including patients whose normal liver tissue volume is less than 700 ml in the radiotherapy plan; 6. Patients with significant concurrent diseases, such as: (1) Active coronary artery disease or a history of myocardial infarction within the past 6 months; (2) Heart failure with New York Heart Association (NYHA) class > 2; (3) Receive hemodialysis or peritoneal dialysis; (4) Active and uncontrolled infections, except chronic viral hepatitis; (5) Human immunodeficiency virus (HIV) infection; (6) uncontrollable or difficult-to-control diabetes; (7) Active gastrointestinal bleeding without definitive treatment within 30 days; (8) Receive organ transplantation, including but not limited to liver transplantation; (9) A history of alcohol or drug abuse within 3 months; (10) Other unstable mental illnesses, abnormal test results or other comorbidities (in the opinion of the investigator, these conditions make the patient participate in the study with unsafe factors, or may affect study compliance or study results); 7. Female patients who are pregnant, lactating or planning to conceive.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| safety; | — |
Secondary
| Measure | Time frame |
|---|---|
| Objective response rate;Overall survival; | — |
Countries
China
Contacts
Public ContactLiu Jingfeng
Fujian Cancer Hospital
Outcome results
None listed