Transitional Growth Hormone Deficiency
Conditions
Interventions
Experimental group:polyethylene glycol recombinant human growth hormone injection
Sponsors
The Children's Hospital of Zhejiang University School of Medicine
Eligibility
Sex/Gender
All
Age
No minimum to 26 Years
Inclusion criteria
Inclusion criteria: 1. Childhood-onset growth hormone deficiency patients, such as patients with benign brain tumors after surgery, are recommended for >= 1 year after surgery; 2. Bone age: female >= 14.5 years old, male >= 16.5 years old; 3. Actual age: female =1 year; 5. Serum GH peak value in insulin resistance test (ITT) <5ng/ml; 6. When other hormones (such as glucocorticoids, thyroid hormones) are deficient, they should have received other hormone replacement therapy, and the investigator judged that the condition was stable before enrollment; 7. The subject is willing and able to cooperate in completing scheduled visits, treatment plans and laboratory tests,and sign a written informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients with abnormal renal function (Cr> the upper limit of normal value); 2. Patients with abnormal liver function caused by hepatotropic virus or other inherited metabolic liver diseases (except for abnormal liver function caused by fatty liver) 3. Those with chronic diseases that affect bone metabolism and body composition for a long time (including but not limited to renal rickets, hypophosphatemic rickets, abnormal parathyroid function or Cushing syndrome, etc.); 4. Diabetic patients; 5. BMI>=28kg/m2; 6. Female patients who are pregnant or breastfeeding, or have a positive baseline pregnancy test; 7. Known to be highly allergic or allergic to the test drugs in this study; 8. Those who have participated in clinical trials of other drugs within 3 months; 9. Other conditions deemed inappropriate by the investigator to be included in this clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Body composition; | — |
Secondary
| Measure | Time frame |
|---|---|
| Bone mineral density;Waist Circumference;Hip circumference;Body mass index; | — |
Countries
China
Contacts
Public ContactFu Junfen
Children's Hospital of Zhejiang University School of Medicine
Outcome results
None listed