Painless gastrointestinal endoscopy
Conditions
Interventions
Control group:After administering 5ug of sufentanil for 1 min, inject propofol at a rate of 0.5ml/min until the patient lost consciousness, and 5ml of propofol was added intraoperatively as needed
Experimental group1:After administering 0.05mg/kg of esesketamine for 1 min, inject propofol at a rate of 0.5ml/min until the patient lost consciousness, and 5ml of propofol was added intraoperative
Experimental group2:After administering 0.10mg/kg of esesketamine for 1 min, inject propofol at a rate of 0.5ml/min until the patient lost consciousness, and 5ml of propofol was added intraoperatively
Experimental group3:After administering 0.15mg/kg of esesketamine for 1 min, inject propofol at a rate of 0.5ml/min until the patient lost consciousness, and 5ml of propofol was added intraoperatively
Sponsors
Rizhao Central Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. ASA I~II; 2. Aged 18 to 60 years; 3. All patients had no mental or neurological disorders before surgery; 4. Good heart, lung, liver and kidney functions; 5. Activity equivalent > 4MET.
Exclusion criteria
Exclusion criteria: 1. Preoperative oral sedatives and antidepressants; 2. Preoperative assessment of difficult airway; 3. Patients with Mallampati grade > III.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Anesthesia effect;Respiratory changes;Changes in hemodynamics;The recovery time;Awake score;Patient satisfaction; | — |
Secondary
| Measure | Time frame |
|---|---|
| Application dose of propofol; | — |
Countries
China
Contacts
Public ContactXu Jiping
Rizhao Central Hospital
Outcome results
None listed