Anesthetic
Conditions
Interventions
experimental group :Before skin cutting, 0.5mg/kg ketamine was injected intravenously
control group:The same amount of normal saline was injected intravenously before skin cutting
Sponsors
Anhui Provincial Cancer Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria for breast cancer; 2. There are indications for radical mastectomy for breast cancer; 3. The American Society of Anesthesiologists (ASA) is graded I to II; 4. Approved by the hospital ethics committee; 5. Informed consent of patients and their families.
Exclusion criteria
Exclusion criteria: 1. Past history of mental illness and drug use; 2. Patients with severe liver and kidney insufficiency; 3. Those who have contraindications to the anesthetic drugs used in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Perioperative anesthetic dosage;Visual Analogue Scale at 1, 2 and 3 days after surgery;Self-rating Anxiety Scale scores were evaluated preoperatively 1 day and postoperative 3 days;Self-rating Depression Scale score were evaluated preoperatively 1 day and postoperative 3 days;The Recovery Quality Rating Scale-40 score were evaluated preoperatively 1 day and postoperative 3 days;The number of anxiety and depression cases preoperatively 1 day and postoperative 3 days; | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of cases/rate of adverse reactions within 3 days after surgery;Incidence of remedial analgesia in the ward within 3 days after operation; | — |
Countries
China
Contacts
Public ContactXiao Yimin
Anhui Provincial Cancer Hospital
Outcome results
None listed