Effect of individualized titration of PEEP in patients with moderate to severe ARDS by electrical impedance tomography: a single center randomized controlled clinical trial

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100048488

Enrollment

Unknown

Registered

2021-07-09

Start date

2021-09-01

Completion date

Unknown

Last updated

2022-03-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute respiratory distress syndrome

Interventions

Control group:ARDS net low PEEP principle to set PEEP

EIT group:Individualized titration of PEEP with EIT

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Patients who meet the Berlin diagnostic criteria of ARDS in 2012 and need invasive mechanical ventilation; 2. Aged >= 18 years; 3. PaO2/FiO2<=200.

Exclusion criteria

Exclusion criteria: 1. Patients with temporary or permanent pacemakers installed; 2. Obesity, body mass index >= 50%; 3. Hemodynamic instability; 4. Patients with severe chronic obstructive pulmonary disease (GOLD III or IV).

Design outcomes

Primary

Measure	Time frame
28 day mortality;	—

Secondary

Measure	Time frame
Oxygenation index(PaO2/FiO2);Free mechanical ventilation time during ICU;Driving pressure;Global inhomogeneity index;Regional ventilation delay;	—

Countries

China

Contacts

Public ContactWang Qiaosheng

the first affiliated hospital of university of south China

docwqs@163.com+86 734 8578606

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026