None listed
Conditions
Interventions
Group A:0.375% ropivacaine 30ml
Group B:0.375% ropivacaine + 0.25ug/kg dexamethasone 30ml
Group C:0.375% ropivacaine + 0.5ug/kg dexamethasone 30ml
Group D:0.375% ropivacaine + 0.75ug/kg dexamethasone 30ml
Group E:0.375% ropivacaine + 1ug/kg dextromethorphan 30ml
Sponsors
Tongren Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-75 years, planning to undergo elective foot and ankle surgery under general anesthesia in Beijing Tongren Hospital; 2. ASA level 1-3; 3. Single foot surgery, the estimated operation time is 0-3 hours; 4. BMI 18-30 kg/m^2; 5. Agree to participate in this study and sign the informed consent form before surgery.
Exclusion criteria
Exclusion criteria: 1. Anesthesia contraindications (coagulation disorders, infection at the puncture site, allergic to general or local anesthetics); 2. Predictably difficult airway; 3. Combined with central or peripheral neuropathy; 4. Pregnant women and lactating women; 5. Patients who use opioids for a long time; 6. Abnormal liver and kidney function: ALT and/or AST>2xULN, or TBIL>=1.5xULN; serum creatinine>112 µmol/L, or received dialysis treatment within 28 days before surgery; 7. Diabetic patients with unsatisfactory control of blood sugar (fasting blood sugar >= 11mmol/L during the screening period); 8. Participated in other clinical trials within 30 days; 9. Patients with combined tumor; 10. Charcot-type osteoarthropathy; 11. History of long-term use of hormones.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| first pain time;time to first request analgesia; | — |
Secondary
| Measure | Time frame |
|---|---|
| pain score;adverse effect( itch, dizzy,nausa,consciousness, retention of urine);analgesic need in 24 and 48h;overall satisfaction;adverse effects of nerve block; | — |
Countries
China
Contacts
Public ContactWang Guyan
Beijng Tongren Hospital
Outcome results
None listed